Complement-mediated thrombotic microangiopathy on a background of Alport syndrome: A case report

Craig Peter Coorey; Theo de Malmanche; Angela Chou; Martin Feddersen

doi:10.1111/nep.14305

Complement-mediated thrombotic microangiopathy on a background of Alport syndrome: A case report

Nephrology (Carlton). 2024 Oct;29(10):688-690. doi: 10.1111/nep.14305. Epub 2024 Apr 11.

Authors

Craig Peter Coorey^{1

2}, Theo de Malmanche^{3

4}, Angela Chou⁵, Martin Feddersen¹

Affiliations

¹ Renal Unit, Gosford Hospital, Gosford, New South Wales, Australia.
² School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia.
³ Immunology, NSW Health Pathology, Newcastle, New South Wales, Australia.
⁴ School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia.
⁵ Department of Anatomical Pathology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

PMID: 38604610
DOI: 10.1111/nep.14305

Abstract

Here we present a case of complement-mediated thrombotic microangiopathy (TMA) in a patient who has a background of Stage 5 chronic kidney disease secondary to Alport syndrome. We explain our approach to the diagnosis of TMA, especially the reliance on non-renal manifestations of TMA and the role of kidney biopsy given there was a background of advanced kidney impairment at baseline.

Keywords: Alport syndrome (hereditary nephritis); acute kidney injury; thrombotic microangiopathy.

Publication types

Case Reports

MeSH terms

Adult
Biopsy
Complement Activation
Humans
Kidney / pathology
Male
Nephritis, Hereditary* / complications
Nephritis, Hereditary* / diagnosis
Thrombotic Microangiopathies* / diagnosis
Thrombotic Microangiopathies* / etiology
Treatment Outcome