Complement-mediated thrombotic microangiopathy on a background of Alport syndrome: A case report

Nephrology (Carlton). 2024 Apr 11. doi: 10.1111/nep.14305. Online ahead of print.


Here we present a case of complement-mediated thrombotic microangiopathy (TMA) in a patient who has a background of Stage 5 chronic kidney disease secondary to Alport syndrome. We explain our approach to the diagnosis of TMA, especially the reliance on non-renal manifestations of TMA and the role of kidney biopsy given there was a background of advanced kidney impairment at baseline.

Keywords: Alport syndrome (hereditary nephritis); acute kidney injury; thrombotic microangiopathy.

Publication types

  • Case Reports