MDSC expansion during HIV infection: regulators, ART and immune reconstitution

Mahmoud Mohammad Yaseen; Nizar Mohammad Abuharfeil; Homa Darmani

doi:10.1038/s41435-024-00272-9

MDSC expansion during HIV infection: regulators, ART and immune reconstitution

Genes Immun. 2024 Apr 11. doi: 10.1038/s41435-024-00272-9. Online ahead of print.

Authors

Mahmoud Mohammad Yaseen¹, Nizar Mohammad Abuharfeil², Homa Darmani²

Affiliations

¹ Department of Biotechnology and Genetic Engineering, Faculty of Science and Arts, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan. mahmoudhiv1@yahoo.com.
² Department of Biotechnology and Genetic Engineering, Faculty of Science and Arts, Jordan University of Science and Technology, P.O. Box 3030, Irbid, 22110, Jordan.

PMID: 38605259
DOI: 10.1038/s41435-024-00272-9

Abstract

Myeloid-derived suppressor cells (MDSCs) become expanded in different pathological conditions including human immunodeficiency virus (HIV) infection and this may worsen the disease status and accelerate disease progression. In HIV infection, MDSCs suppress anti-HIV immune responses and hamper immune reconstitution. Understanding the factors and mechanisms of MDSC expansion during HIV infection is central to understanding the pathophysiology of HIV infection. This may pave the way to developing new therapeutic targets or strategies. In this work we addressed (i) the mechanisms that regulate MDSC expansion, (ii) the impact of antiretroviral therapy (ART) on the frequency of MDSCs during HIV infection; (iii) the impact of MDSCs on immune reconstitution during successful ART; and (iv) the potential of MDSCs as a therapeutic target.

Publication types

Review