New Antibacterial 1,3,4-Thiadiazole Derivatives With Pyridine Moiety

Chem Biodivers. 2024 Jun;21(6):e202400522. doi: 10.1002/cbdv.202400522. Epub 2024 May 16.

Abstract

1,3,4-Thiadiazole compounds were synthesized using pyridine carboxylic acid derivatives and thiosemicarbazide derivatives. The molecular structures of the resulting compounds were characterized by spectroscopic methods such as ATR-FTIR, 1H-NMR, and elemental analysis. Its compounds were also examined for their antibacterial properties against some strains of bacteria. Five synthesized compounds showed varying antibacterial effects on Escherichia coli, Salmonella kentucky, Bacillus substilis and Klebsiella pneumoniae. This result revealed that some of the resulting compounds could be antibacterial agents.

Keywords: 1,3,4-thiadiazole; Pyridine; antibacterial.

MeSH terms

  • Anti-Bacterial Agents* / chemical synthesis
  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / pharmacology
  • Escherichia coli* / drug effects
  • Klebsiella pneumoniae* / drug effects
  • Microbial Sensitivity Tests*
  • Molecular Structure
  • Pyridines* / chemical synthesis
  • Pyridines* / chemistry
  • Pyridines* / pharmacology
  • Structure-Activity Relationship
  • Thiadiazoles* / chemical synthesis
  • Thiadiazoles* / chemistry
  • Thiadiazoles* / pharmacology

Substances

  • Anti-Bacterial Agents
  • Thiadiazoles
  • Pyridines
  • 1,3,4-thiadiazole
  • pyridine