Inhibition of B16-BL6 melanoma growth in mice by methionine-enkephalin

J Natl Cancer Inst. 1985 Aug;75(2):341-4.


The antitumor effect of methionine-enkephalin [( Met]enkephalin) was demonstrated in C57BL/6J mice inoculated with B16-BL6 melanoma cells. Local subcutaneous tumor growth was inhibited with a 50-micrograms dose daily for 7 or 14 days. The antitumor effect of [Met]enkephalin was inhibited by the administration of the opioid receptor antagonist naloxone. Naloxone alone had no significant effect on tumor growth.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Enkephalin, Methionine / antagonists & inhibitors
  • Enkephalin, Methionine / pharmacology*
  • Male
  • Melanoma / pathology*
  • Mice
  • Mice, Inbred C57BL
  • Naloxone / pharmacology
  • Neoplasm Transplantation


  • Naloxone
  • Enkephalin, Methionine