BREAST CANCER-MODULATED OMENTIN AND VASPIN PLASMA LEVELS

Georgian Med News. 2024 Feb:(347):66-69.

Abstract

Omentin and vaspin levels have been shown to change in many inflammatory diseases, the present study aimed to evaluate the omentin and vaspin levels in breast cancer patients. To do so serum samples were collected and analysed for omentin, vaspin, renal and liver function tests. The levels of creatinine (p<0.01) and urea (p<0.05) showed substantial increases, while omentin and Vaspin levels notably decreased (p<0.05). Additionally, breast cancer patients exhibited significantly higher levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine transaminase (ALT) compared to the control group (p<0.05). In comparison to the control group, individuals with breast cancer demonstrated reduced blood concentrations of omentin and vaspin and elevated levels of creatinine and urea. Additionally, liver function testing indicated lower levels of Alanine transaminase (ALT), Alkaline phosphatase (ALP), and Aspartate aminotransferase (AST) in breast cancer patients. Breast cancer patients had lower levels of omentin and vaspin, and higher levels of creatinine and urea compared to the control group. Liver function tests also indicated lower levels of AST, ALP, and ALT in breast cancer patients compared to the control group.

MeSH terms

  • Alanine Transaminase
  • Alkaline Phosphatase
  • Aspartate Aminotransferases
  • Breast Neoplasms*
  • Creatinine
  • Female
  • Humans
  • Urea

Substances

  • Alanine Transaminase
  • Alkaline Phosphatase
  • Aspartate Aminotransferases
  • Creatinine
  • Urea
  • ITLN1 protein, human
  • SERPINA12 protein, human