Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting

Christoph Gruber; Lea Krautner; Valter Bergant; Vincent Grass; Zhe Ma; Lara Rheinemann; Ariane Krus; Friederike Reinhardt; Lyupka Mazneykova; Marianne Rocha-Hasler; Dong-Jiunn Jeffery Truong; Gil Gregor Westmeyer; Andreas Pichlmair; Gregor Ebert; Florian Giesert; Wolfgang Wurst

doi:10.1038/s41421-024-00672-1

Engineered, nucleocytoplasmic shuttling Cas13d enables highly efficient cytosolic RNA targeting

Cell Discov. 2024 Apr 12;10(1):42. doi: 10.1038/s41421-024-00672-1.

Authors

Christoph Gruber^{1

2}, Lea Krautner³, Valter Bergant⁴, Vincent Grass⁴, Zhe Ma⁵, Lara Rheinemann⁴, Ariane Krus³, Friederike Reinhardt³, Lyupka Mazneykova³, Marianne Rocha-Hasler⁵, Dong-Jiunn Jeffery Truong^{6

7}, Gil Gregor Westmeyer^{6

7

8}, Andreas Pichlmair^{4

9}, Gregor Ebert¹⁰, Florian Giesert¹¹, Wolfgang Wurst^{12

13

14

15}

Affiliations

¹ Institute of Developmental Genetics, Helmholtz Munich, Oberschleißheim, Germany. christoph.gruber@helmholtz-munich.de.
² TUM School of Life Sciences, Technical University of Munich, Freising, Germany. christoph.gruber@helmholtz-munich.de.
³ Institute of Developmental Genetics, Helmholtz Munich, Oberschleißheim, Germany.
⁴ Technical University of Munich, School of Medicine and Health, Institute of Virology, Munich, Germany.
⁵ Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany.
⁶ Department of Bioscience, TUM School of Natural Sciences, Technical University of Munich, Munich, Germany.
⁷ Institute for Synthetic Biomedicine, Helmholtz Munich, Oberschleißheim, Germany.
⁸ TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
⁹ German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany.
¹⁰ Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany. gregor.ebert@helmholtz-munich.de.
¹¹ Institute of Developmental Genetics, Helmholtz Munich, Oberschleißheim, Germany. florian.giesert@helmholtz-munich.de.
¹² Institute of Developmental Genetics, Helmholtz Munich, Oberschleißheim, Germany. wolfgang.wurst@helmholtz-munich.de.
¹³ TUM School of Life Sciences, Technical University of Munich, Freising, Germany. wolfgang.wurst@helmholtz-munich.de.
¹⁴ Deutsches Zentrum für Psychische Gesundheit (DZPG), Site Munich-Augsburg, Germany. wolfgang.wurst@helmholtz-munich.de.
¹⁵ German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. wolfgang.wurst@helmholtz-munich.de.

No abstract available

Publication types

Letter

Publication types

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