The Role of Epigenetic Factors in the Pathogenesis of Psoriasis

Int J Mol Sci. 2024 Mar 29;25(7):3831. doi: 10.3390/ijms25073831.


Psoriasis is a chronic inflammatory skin disease, the prevalence of which is increasing. Genetic, genomic, and epigenetic changes play a significant role in the pathogenesis of psoriasis. This review summarizes the impact of epigenetics on the development of psoriasis and highlights challenges for the future. The development of epigenetics provides a basis for the search for genetic markers associated with the major histocompatibility complex. Genome-wide association studies have made it possible to link psoriasis to genes and therefore to epigenetics. The acquired knowledge may in the future serve as a solid foundation for developing newer, increasingly effective methods of treating psoriasis. In this narrative review, we discuss the role of epigenetic factors in the pathogenesis of psoriasis.

Keywords: HLA; epigenetics; genetics; genome-wide association studies; ncRNA; psoriasis.

Publication types

  • Review

MeSH terms

  • Epigenesis, Genetic
  • Epigenomics
  • Genome-Wide Association Study*
  • Humans
  • Psoriasis* / genetics
  • Skin

Grants and funding

This research received no external funding.