Applications of Flow Cytometry in Drug Discovery and Translational Research

Int J Mol Sci. 2024 Mar 29;25(7):3851. doi: 10.3390/ijms25073851.

Abstract

Flow cytometry is a mainstay technique in cell biology research, where it is used for phenotypic analysis of mixed cell populations. Quantitative approaches have unlocked a deeper value of flow cytometry in drug discovery research. As the number of drug modalities and druggable mechanisms increases, there is an increasing drive to identify meaningful biomarkers, evaluate the relationship between pharmacokinetics and pharmacodynamics (PK/PD), and translate these insights into the evaluation of patients enrolled in early clinical trials. In this review, we discuss emerging roles for flow cytometry in the translational setting that supports the transition and evaluation of novel compounds in the clinic.

Keywords: cell biology; drug discovery; flow cytometry; immuno-oncology; immunology; oncology; pharmacology; translational research; vaccines.

Publication types

  • Review

MeSH terms

  • Drug Discovery
  • Flow Cytometry
  • Humans
  • Research Design
  • Translational Research, Biomedical*
  • Translational Science, Biomedical*

Grants and funding

This research received no external funding.