Orchestrating neuronal activity-dependent translation via the integrated stress response protein GADD34

Xingzhi He; Wenwen Li; Huan Ma

doi:10.1016/j.tins.2024.03.008

Orchestrating neuronal activity-dependent translation via the integrated stress response protein GADD34

Trends Neurosci. 2024 May;47(5):319-321. doi: 10.1016/j.tins.2024.03.008. Epub 2024 Apr 13.

Authors

Xingzhi He¹, Wenwen Li¹, Huan Ma²

Affiliations

¹ Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou 311121, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou 310058, China.
² Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Liangzhu Laboratory, School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University, Hangzhou 311121, China; NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou 310058, China; Research Units for Emotion and Emotion disorders, Chinese Academy of Medical Sciences, Beijing 100000, China. Electronic address: mah@zju.edu.cn.

PMID: 38614892
DOI: 10.1016/j.tins.2024.03.008

Abstract

In a recent study, Oliveira and colleagues revealed how growth arrest and DNA damage-inducible protein 34 (GADD34), an effector of the integrated stress response, initiates the translation of synaptic plasticity-related mRNAs following brain-derived neurotrophic factor (BDNF) stimulation. This work suggests that GADD34 may link transcriptional products with translation control upon neuronal activation, illuminating how protein synthesis is orchestrated in neuronal plasticity.

Keywords: BDNF; excitation–transcription coupling; neuronal plasticity; protein synthesis; transcription; translation.

MeSH terms

Animals
Brain-Derived Neurotrophic Factor / metabolism
Humans
Neuronal Plasticity* / physiology
Neurons* / metabolism
Neurons* / physiology
Protein Biosynthesis* / physiology
Protein Phosphatase 1* / metabolism
Stress, Physiological / physiology