Single-center Incidence and Patterns of Stroke in Early Renal Anhydramnios after Serial Amnioinfusions

Dawn B Lammert; Jena L Miller; Meredith A Atkinson; Lisa R Sun

doi:10.1016/j.jpeds.2024.114053

Single-center Incidence and Patterns of Stroke in Early Renal Anhydramnios after Serial Amnioinfusions

J Pediatr. 2024 Apr 12:114053. doi: 10.1016/j.jpeds.2024.114053. Online ahead of print.

Authors

Dawn B Lammert¹, Jena L Miller², Meredith A Atkinson³, Lisa R Sun⁴

Affiliations

¹ Johns Hopkins School of Medicine, Department of Neurology, Division of Child Neurology, Baltimore, Maryland;. Electronic address: dlammer2@jhmi.edu.
² Johns Hopkins School of Medicine, Department of Obstetrics and Gynecology, Johns Hopkins Center for Fetal Therapy, Baltimore, MD.
³ Johns Hopkins School of Medicine, Department of Pediatrics, Division of Pediatric Nephrology, Baltimore, MD.
⁴ Johns Hopkins School of Medicine, Department of Neurology, Division of Child Neurology, Baltimore, Maryland.

PMID: 38615944
DOI: 10.1016/j.jpeds.2024.114053

Abstract

The Renal Anhydramnios Fetal Therapy (RAFT) trial is a study of serial amnioinfusions to prevent lethal neonatal pulmonary hypoplasia from early renal anhydramnios. Infant neurologic outcomes were not originally evaluated. We describe the high incidence of stroke observed among infants in the treatment arm of the trial at our center.

Keywords: cerebral ischemia; dysplastic kidney; renal agenesis.