Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells

Nature. 1985 Aug 22-28;316(6030):701-5. doi: 10.1038/316701a0.


The partial amino-acid sequence of purified human transforming growth factor-beta (TGF-beta) was used to identify a series of cDNA clones encoding the protein. The cDNA sequence indicates that the 112-amino acid monomeric form of the natural TGF-beta homodimer is derived proteolytically from a much longer precursor polypeptide which may be secreted. TGF-beta messenger RNA is synthesized in various normal and transformed cells.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • DNA / analysis*
  • Humans
  • Neoplasms / analysis*
  • Peptides / genetics*
  • RNA, Messenger / analysis
  • Transforming Growth Factors


  • Peptides
  • RNA, Messenger
  • Transforming Growth Factors
  • DNA

Associated data

  • GENBANK/X02812