OMA1 clears traffic jam in TOM tunnel in mammals

J Cell Biol. 2024 May 6;223(5):e202403190. doi: 10.1083/jcb.202403190. Epub 2024 Apr 15.

Abstract

Using an engineered mitochondrial clogger, Krakowczyk et al. (https://doi.org/10.1083/jcb.202306051) identified the OMA1 protease as a critical component that eliminates import failure at the TOM translocase in mammalian cells, providing a novel quality control mechanism that is distinct from those described in yeast.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Animals
  • Mammals*
  • Metalloproteases* / metabolism
  • Mitochondria
  • Mitochondrial Precursor Protein Import Complex Proteins*
  • Mitochondrial Proteins* / metabolism
  • Peptide Hydrolases
  • Saccharomyces cerevisiae / genetics

Substances

  • Mitochondrial Precursor Protein Import Complex Proteins
  • Peptide Hydrolases
  • Metalloproteases
  • Mitochondrial Proteins