Potentiometric sensing of ibuprofen over ferric oxide doped chitosan grafted polypyrrole-based electrode

Manisha Sharma; Ashok K Sharma; Saroj Kr Shukla

doi:10.1016/j.ijbiomac.2024.131598

Potentiometric sensing of ibuprofen over ferric oxide doped chitosan grafted polypyrrole-based electrode

Int J Biol Macromol. 2024 Apr 15;268(Pt 1):131598. doi: 10.1016/j.ijbiomac.2024.131598. Online ahead of print.

Authors

Manisha Sharma¹, Ashok K Sharma², Saroj Kr Shukla³

Affiliations

¹ Thin Film Laboratory, Department of Chemistry, Deenbandhu Chhotu Ram University of Science and Technology, Murthal 131039, India; Department of Polymer Science, Bhaskaracharya College of Applied Sciences, University of Delhi, Delhi 110075, India.
² Thin Film Laboratory, Department of Chemistry, Deenbandhu Chhotu Ram University of Science and Technology, Murthal 131039, India. Electronic address: draksharma.chem@dcrustm.org.
³ Department of Polymer Science, Bhaskaracharya College of Applied Sciences, University of Delhi, Delhi 110075, India. Electronic address: sarojshukla2003@yahoo.co.in.

PMID: 38621570
DOI: 10.1016/j.ijbiomac.2024.131598

Abstract

The present work demonstrates the correlation between structure, properties, and self-sensing protocols of in situ prepared ferric oxide doped grafted copolymer composite, comprised of ferric oxide, chitosan, and polypyrrole (α-Fe₂O₃-en-CHIT-g-PPy) for residual ibuprofen present in natural and artificial samples. The chemical structure, morphology, functionality, and physio-mechanical properties of the composite were determined by Fourier transform infrared spectrometer (FT-IR), Raman spectra, X-ray diffraction (XRD), Scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), Two probe method, and standard ASTM techniques to explore sensing nature. The results confirm the evolution of axially aligned structure against 110 planes of α-Fe₂O₃ and chemically functionalized expanded polymer matrix during in-situ chemical polymerization of pyrrole, with better porosity, interactivity, and improved electrical conductivity i.e. 7.32 × 10^-3 S cm^-1. Further, a thin film of prepared composite coated on an ITO glass plate was explored for potentiometric sensing of ibuprofen (IBU) present in artificial and natural samples without the use of any additional energy sources. The observed sensing parameters are the sensing ranging 0.5 μM to 100.0 μM, sensitivity 2.5081 mV μM^-1 cm^-2, response time 50 s, recovery time 10 s, and stability for 60 days. The sensing mechanism of the IBU sensor and effective charge transfer in the electrode was also discussed based on changes in IR spectra of the electrode recorded before and after sensing due to surface oxidation of IBU due to the presence of iron and doping effect of iron oxide in the composite.

Keywords: Potentiometric ibuprofen sensing; Sensing mechanism; Sensing parameters; α-Fe(2)O(3)-en-CHIT-g-PPy.