Severe Coagulation Dysfunction caused by Vitamin K Deficiency in an Elderly Patient

Clin Lab. 2024 Apr 1;70(4). doi: 10.7754/Clin.Lab.2023.231001.

Abstract

Background: Vitamin K deficiency can lead to severe coagulation dysfunction, which may be dangerous and fatal, especially in patients undergoing surgery.

Methods: We report an 84-year-old male patient with gallstones and cholecystitis who had a severe coagulation disorder without bleeding symptoms after endoscopic papillary balloon dilation for removal of bile duct stones. After vitamin K supplementation, the coagulation dysfunction was corrected the next day.

Results: In this case, long-term antibiotic treatment, inadequate diet, and abnormal liver function led to coagulation dysfunction. After vitamin K supplementation, the blood coagulation disorder was corrected and serious consequences were prevented. Significantly elevated coagulation function was considered to be caused by vitamin K deficiency.

Conclusions: This case indicates that coagulation dysfunction caused by vitamin K deficiency may occur within a few days. Laboratory personnel should fully understand the risks of vitamin K deficiency in elderly patients undergoing surgery with severely restricted diet, impaired absorption, and long-term use of cephalosporin anti-inflammatory therapy, and promptly remind clinical doctors.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use
  • Blood Coagulation Disorders*
  • Gallstones* / complications
  • Gallstones* / drug therapy
  • Humans
  • Male
  • Vitamin K / therapeutic use
  • Vitamin K Deficiency* / complications

Substances

  • Vitamin K
  • Anti-Bacterial Agents