Fibroblast Growth Factor 6

Jennelle Smith; Loydie A Jerome-Majewska

doi:10.1016/j.diff.2024.100780

Fibroblast Growth Factor 6

Differentiation. 2024 Apr 10:137:100780. doi: 10.1016/j.diff.2024.100780. Online ahead of print.

Authors

Jennelle Smith¹, Loydie A Jerome-Majewska²

Affiliations

¹ Department of Anatomy and Cell Biology, McGill University, Montreal, QC, H3A 2B2, Canada; Research Institute of the McGill University Health Centre at Glen Site, Montreal, QC, H4A 3J1, Canada.
² Department of Anatomy and Cell Biology, McGill University, Montreal, QC, H3A 2B2, Canada; Department of Human Genetics, McGill University, Montreal, QC, H3A 0G1, Canada; Research Institute of the McGill University Health Centre at Glen Site, Montreal, QC, H4A 3J1, Canada; Department of Paediatrics, McGill University, Montreal, QC, H4A 3J1, Canada. Electronic address: loydie.majewska@mcgill.ca.

PMID: 38626632
DOI: 10.1016/j.diff.2024.100780

Abstract

Fibroblast Growth Factor 6 (FGF6), also referred to as HST2 or HBGF6, is a member of the Fibroblast Growth Factor (FGF), the Heparin Binding Growth Factor (HBGF) and the Heparin Binding Secretory Transforming Gene (HST) families. The genomic and protein structure of FGF6 is highly conserved among varied species, as is its expression in muscle and muscle progenitor cells. Like other members of the FGF family, FGF6 regulates cell proliferation, differentiation, and migration. Specifically, it plays key roles in myogenesis and muscular regeneration, angiogenesis, along with iron transport and lipid metabolism. Similar to others from the FGF family, FGF6 also possesses oncogenic transforming activity, and as such is implicated in a variety of cancers.

Keywords: FGF; FGF6; Muscular regeneration; Myogenesis; Proto-oncogene.