Perioperative and Oncological Outcomes of Partial Versus Radical Nephrectomy for Complex Renal Tumors (RENAL Score ≥ 7): Systematic Review and Meta-Analysis

Zhiqiang Zeng; Si Ge; Yunxiang Li; Lijian Gan; Chunyang Meng; Kangsen Li; Zuoping Wang; Lei Zheng

doi:10.1245/s10434-024-15223-x

Perioperative and Oncological Outcomes of Partial Versus Radical Nephrectomy for Complex Renal Tumors (RENAL Score ≥ 7): Systematic Review and Meta-Analysis

Ann Surg Oncol. 2024 Apr 17. doi: 10.1245/s10434-024-15223-x. Online ahead of print.

Authors

Zhiqiang Zeng^#^{1

2}, Si Ge^#^{1

2}, Yunxiang Li^#^{3

4

5}, Lijian Gan^{1

6}, Chunyang Meng^{1

6}, Kangsen Li^{1

6}, Zuoping Wang^{1

6}, Lei Zheng^{1

6}

Affiliations

¹ Nanchong Central Hospital, Nanchong, Sichuan, China.
² Department of Urology, School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan, China.
³ Nanchong Central Hospital, Nanchong, Sichuan, China. liyunxiang369@126.com.
⁴ Department of Urology, School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan, China. liyunxiang369@126.com.
⁵ Department of Urology, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College (University), Nanchong, Sichuan, China. liyunxiang369@126.com.
⁶ Department of Urology, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College (University), Nanchong, Sichuan, China.

^# Contributed equally.

PMID: 38630418
DOI: 10.1245/s10434-024-15223-x

Abstract

Objective: Which is superior, partial nephrectomy (PN) or radical nephrectomy (RN), for the treatment of complex renal tumours (RENAL or score ≥ 7)?

Methods: This systematic review and meta-analysis was conducted in accordance with the PRISMA statement. A systematic search of the literature published before November 2023 was conducted using Pubmed, Embase, Cochran, and Web of Science libraries. We included studies comparing perioperative and oncologic outcomes of partial nephrectomy and radical nephrectomy for complex renal tumors.

Results: A total of 2602 patients from six studies meeting the criteria were included. The PN group had a longer operative time, increased estimated blood loss, and major complications but a smaller reduction in renal function. There were no significant differences in complications, length of hospital stay, and blood transfusion. In terms of oncological outcomes, the PN group had longer OS, CSS, and no significant difference in RFS.

Conclusions: For complex renal tumours, PN requires more operative time and has a higher chance of complications in the short term. However, in long-term follow-up, PN has a small decrease in renal function with longer OS and CSS.

Keywords: Complex renal tumours; Meta-analysis; Partial nephrectomy (PN); Radical nephrectomy (RN).

Publication types

Review