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. 2024 Apr 26;87(4):1067-1074.
doi: 10.1021/acs.jnatprod.4c00022. Epub 2024 Apr 17.

Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia

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Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia

Ulises G Castillo et al. J Nat Prod. .

Abstract

A search for anti-trypanosomal natural compounds from plants collected in El Salvador, a country particularly endemic for Chagas disease, resulted in the isolation of five lignan-type compounds (1-5) from Peperomia pseudopereskiifolia. The lignan derivatives 1, 2, and 4 are new. Their absolute configuration was determined by chemical derivatization. Compounds 1, 5, 6, and 8 exhibited anti-trypanosomal activity against the amastigote form of T. cruzi comparable to that of the existing drug benznidazole.

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