Velopharyngeal dysfunction and speech-related characteristics in craniofacial microsomia: a retrospective analysis of 223 patients

R W Renkema; K R R Ramdat Misier; W Rooijers; A Osolos; H H W de Gier; H G Poldermans; B L Padwa; D J Dunaway; C J J M Caron; M J Koudstaal

doi:10.1016/j.ijom.2024.04.001

Velopharyngeal dysfunction and speech-related characteristics in craniofacial microsomia: a retrospective analysis of 223 patients

Int J Oral Maxillofac Surg. 2024 Apr 16:S0901-5027(24)00095-X. doi: 10.1016/j.ijom.2024.04.001. Online ahead of print.

Authors

Affiliations

¹ The Dutch Craniofacial Center, Department of Oral and Maxillofacial Surgery, Erasmus University Medical Center, Sophia's Children's Hospital, Rotterdam, the Netherlands. Electronic address: r.renkema@erasmusmc.nl.
² The Dutch Craniofacial Center, Department of Oral and Maxillofacial Surgery, Erasmus University Medical Center, Sophia's Children's Hospital, Rotterdam, the Netherlands.
³ The Craniofacial Unit, Great Ormond Street Hospital, London, UK.
⁴ Department of Otorhinolaryngology and Head and Neck Surgery, Sophia Children's Hospital, Erasmus Medical Center, Rotterdam, the Netherlands.
⁵ The Craniofacial Centre, Boston Children's Hospital, Boston, MA, USA.
⁶ The Dutch Craniofacial Center, Department of Oral and Maxillofacial Surgery, Erasmus University Medical Center, Sophia's Children's Hospital, Rotterdam, the Netherlands; The Craniofacial Unit, Great Ormond Street Hospital, London, UK; The Craniofacial Centre, Boston Children's Hospital, Boston, MA, USA.

PMID: 38631989
DOI: 10.1016/j.ijom.2024.04.001

Abstract

This study aimed to document the prevalence, severity, and risk factors of velopharyngeal dysfunction (VPD) in craniofacial microsomia (CFM) and to analyse differences in VPD-related speech characteristics between CFM patients without cleft lip and/or palate (CL/P), CFM patients with CL/P, and CL/P patients without CFM (control). A total of 223 patients with CFM were included, of whom 59 had a CL/P. Thirty-four CFM patients had VPD, including 20 with a CL/P. VPD was significantly more prevalent in CFM with CL/P than in CFM without CL/P (odds ratio (OR) 4.1, 95% confidence interval (CI) 1.9-8.7; P < 0.001). Multivariate logistic regression showed a significant association between CL/P and VPD in CFM patients (OR 7.4, 95% CI 2.1-26.3; P = 0.002). The presence of VPD was not associated with sex, the laterality or severity of CFM. Speech problems related to VPD appeared to be similar among the different groups (CFM without CL/P, CFM with CL/P, CL/P without CFM). As 15.2% of all CFM patients and 8.5% of CFM patients without CL/P had VPD, it is proposed that all patients with CFM, with or without CL/P, should be assessed by a speech and language therapist for the potential risk of VPD.

Keywords: Craniofacial abnormalities; Goldenhar syndrome; Hemifacial microsomia; Inadequate velopharyngeal closure; Velopharyngeal incompetence; Velopharyngeal insufficiency.