New insights into the vitamin D/PTH axis in endocrine-driven metabolic bone diseases

Endocrine. 2024 Sep;85(3):1007-1019. doi: 10.1007/s12020-024-03784-6. Epub 2024 Apr 17.

Abstract

Background: Endocrine regulation of bone metabolisms is the focus of the "Skeletal Endocrinology" series of meetings.

Aims: To report on the outcome of the discussion on the role of vitamin D/PTH axis in endocrine osteopathies held during the 10th Skeletal Endocrinology Meeting which took place in Stresa (Italy) in March 2023.

Outcomes: Vitamin D/PTH axis has relevant influence on several outcomes in the general population and in patients affected by endocrinopathies such as hypoparathyroidism and secreting pituitary adenomas.

Conclusions: Assessing the status of the vitamin D/PTH axis and using vitamin D and PTH as therapeutic agents is mandatory in several endocrine-related bone metabolic conditions.

Keywords: Acromegaly; Cushing’s disease; Hypoparathyroidism; Osteoporosis; Skeletal Endocrinology; Vitamin D.

Publication types

  • Review

MeSH terms

  • Bone Diseases, Metabolic* / etiology
  • Bone Diseases, Metabolic* / metabolism
  • Endocrine System Diseases / metabolism
  • Humans
  • Hypoparathyroidism / metabolism
  • Parathyroid Hormone* / blood
  • Parathyroid Hormone* / metabolism
  • Pituitary Neoplasms / metabolism
  • Vitamin D* / blood
  • Vitamin D* / metabolism

Substances

  • Parathyroid Hormone
  • Vitamin D
  • PTH protein, human