Prostaglandin E-induced polycyclic cutaneous eruption with geometric features

Ananya Shah; Jinia El-Feghaly; Alexandra M Bender

doi:10.1111/pde.15617

Prostaglandin E-induced polycyclic cutaneous eruption with geometric features

Pediatr Dermatol. 2024 Apr 17. doi: 10.1111/pde.15617. Online ahead of print.

Authors

Ananya Shah¹, Jinia El-Feghaly¹, Alexandra M Bender¹

Affiliation

¹ Department of Dermatology, University of Rochester, Rochester, New York, USA.

PMID: 38632884
DOI: 10.1111/pde.15617

Abstract

Prostaglandin E1 (PGE1) is a substance produced by the patent ductus arteriosus that keeps it open. PGE1 can be a lifesaving drug for infants born with ductus-dependent congenital heart disease (CHD) where there is a block of blood flow to the lungs or transposition of great arteries. We present a case of a 36-week, 2-day gestation neonate with CHD who developed bright erythematous annular and polycyclic patches on day 2 of PGE1 administration. When PGE1 dosing was decreased, the rash resolved on its own. Our case demonstrates that PGE1 treatment may not need to be interrupted.

Keywords: cutaneous drug eruption; neonate; polycyclic.

Publication types

Letter