Effect of polymer concentration on the morphology of the PHPMAA- g-PLA graft copolymer nanoparticles produced by microfluidics nanoprecipitation

Nanoscale Adv. 2024 Mar 11;6(8):1992-1996. doi: 10.1039/d3na01038d. eCollection 2024 Apr 16.

Abstract

Successful generation of micelles, vesicles, and/or worms with controllable sizes was achieved through the self-assembly process of the poly[N-(2-hydroxypropyl)]methacrylamide-g-polylactide (PHPMAA-g-PLA) graft copolymer within a microfluidic channel. A product diagram was created to illustrate various morphologies associated with different polymer concentrations, all while maintaining a constant flow velocity ratio between water and the polymer solution.