Background objectives: At present the use of synthetic pesticides to manage insects and other arthropods creates a number of issues that are related to the environment and public health. The goal of the present study was to find the repellent activity of Vitex negundo and Curcuma longa herbal extract against the wild species Simulium (blackfly) bite.
Methods: We have studied Simulium biting behavior and tested the repellency of herbal extract obtained from Vitex negundo L. (Lamiales: Lamiaceae) and Curcuma lonaga L. (Zingiberal: Zingiberaceae) along with their essential oils in three locations in Arunachal Pradesh, India on human volunteers' resistance to Simulium (blackflies). The reported herbal extracts were incorporated to topical drug delivery vehicle as a cream and gel.
Results: The methanolic extract of Vitex negundo cream and gel formulation showed >2 h safety at 5% concentration and >5 h safety at 10% concentration at all the testing sites followed by ethyl acetate extract. Whereas, chloroform extract of Curcuma longa cream and gel formulation provided >1 h safety at 5% concentration and >4 h safety at 10% concentration.
Interpretation conclusion: At an optimum concentration of 10%, the methanolic extract of vitex negundo cream provided complete protection times (CPTs) 320.4, 358.6, and 346.4 minutes, respectively. This finding offers confirmation of the methanolic extract and chloroform extract potential for use in new blackfly repellents.
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