Identification and characterization of a self-regulated repressor of translocation of the Tn3 element

Proc Natl Acad Sci U S A. 1979 Aug;76(8):4020-4. doi: 10.1073/pnas.76.8.4020.


Gene fusions that bring expression of the lacZ gene under control of transcriptional and trnaslational signals within the transposable element Tn3 have been used to study regulation of Tn3-specified proteins. A gene encoding a 21,355-Mr peptide that represses translocation of Tn3 and acts at the level oquenced; amber, missense, and cis-dominant (operator-constitutive) point mutations in this gene have been isolated and characterized.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bacterial Proteins / biosynthesis
  • Bacterial Proteins / genetics
  • Base Sequence
  • DNA Transposable Elements*
  • Escherichia coli / genetics*
  • Genes, Regulator
  • Lac Operon
  • Molecular Weight
  • Mutation
  • Plasmids
  • Repressor Proteins / physiology*
  • Transcription Factors / physiology*


  • Bacterial Proteins
  • DNA Transposable Elements
  • Repressor Proteins
  • Transcription Factors

Associated data

  • GENBANK/M10719