Nanopore sequencing from formalin-fixed paraffin-embedded specimens for copy-number profiling and methylation-based CNS tumor classification
Acta Neuropathol
.
2024 Apr 20;147(1):74.
doi: 10.1007/s00401-024-02731-z.
Authors
Ann-Kristin Afflerbach
1
2
3
,
Anne Albers
4
,
Anton Appelt
1
2
,
Leonille Schweizer
5
6
7
,
Werner Paulus
4
,
Michael Bockmayr
1
2
8
,
Ulrich Schüller
#
1
2
9
,
Christian Thomas
#
10
Affiliations
1
Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
2
Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.
3
Institute for Tumor Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
4
Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149, Münster, Germany.
5
Institute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, Frankfurt Am Main, Germany.
6
German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Heidelberg, Germany.
7
Frankfurt Cancer Institute (FCI), Frankfurt Am Main, Germany.
8
bAIome - Center for Biomedical AI, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
9
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
10
Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149, Münster, Germany. christian.thomas@ukmuenster.de.
#
Contributed equally.
PMID:
38642165
PMCID:
PMC11032293
DOI:
10.1007/s00401-024-02731-z
No abstract available
Keywords:
CNS tumors; Formalin-fixed paraffin-embedded; Nanopore sequencing.
MeSH terms
Formaldehyde
Humans
Methylation
Nanopore Sequencing*
Neoplasms*
Paraffin Embedding
Tissue Fixation
Substances
Formaldehyde