Letter to the editor: fasting decreases expression of microRNAs linked to endothelial pathophysiology in mononuclear cells of healthy subjects

Denise Honeycutt; Arno Schmidt-Trucksäss; Marijke Brink; Nicolle Kränkel; Julia M Kröpfl

doi:10.1007/s10495-024-01971-4

Letter to the editor: fasting decreases expression of microRNAs linked to endothelial pathophysiology in mononuclear cells of healthy subjects

Apoptosis. 2024 Apr 20. doi: 10.1007/s10495-024-01971-4. Online ahead of print.

Authors

Denise Honeycutt¹, Arno Schmidt-Trucksäss², Marijke Brink³, Nicolle Kränkel^{1

4

5}, Julia M Kröpfl⁶

Affiliations

¹ Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité (DHZC), Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.
² Department of Sport, Exercise, and Health, Sport and Exercise Medicine, University of Basel, Grosse Allee 6, Basel, 4052, Switzerland.
³ Department of Biomedicine, Cardiobiology, University Hospital Basel and University of Basel, Hebelstrasse 20, Basel, 4031, Switzerland.
⁴ DZHK (German Centre for Cardiovascular Research), Partner site Berlin, Berlin, Germany.
⁵ Friede Springer - Centre of Cardiovascular Prevention @ Charité, Charité - University Medicine Berlin, Berlin, Germany.
⁶ Department of Sport, Exercise, and Health, Sport and Exercise Medicine, University of Basel, Grosse Allee 6, Basel, 4052, Switzerland. juliamaria.kroepfl@unibas.ch.

PMID: 38642320
DOI: 10.1007/s10495-024-01971-4

Abstract

This study explores how 14-15 h fasting or acute exercise affects immune cell epigenetics, specifically focusing on miRNAs in mononuclear cells. Findings suggest fasting significantly impacts microRNAs associated with endothelial metabolism compared to exercise, but does not directly connect these changes to cell apoptosis or autophagy. This enhances comprehension of cellular self-consumption under health-promoting interventions.

Publication types

Letter