Chronic relapsing myalgia (? Post viral): clinical, histological, and biochemical studies

Aust N Z J Med. 1985 Jun;15(3):305-8. doi: 10.1111/j.1445-5994.1985.tb04042.x.


Two patients with persistent myalgia characterised by onset after an ill-defined systemic illness, marked fluctuations in the severity of the symptoms, and normal neuromuscular examination with the exception of variable muscle tenderness on deep palpation, may have a forme fruste of myalgic encephalomyelitis. Differentiation from psychogenic muscle pain is important in management. Muscle histology revealed non-specific Type II fibre atrophy. Mitochondrial respiration was assayed polarographically in intact organelles in vitro and revealed a mild depression of State 3 respiration rates with Site I and Site II substrates.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chronic Disease
  • Electromyography
  • Female
  • Histocytochemistry
  • Humans
  • Male
  • Mitochondria, Muscle / metabolism
  • Muscles / analysis
  • Muscular Diseases / diagnosis
  • Muscular Diseases / etiology*
  • Muscular Diseases / physiopathology
  • Oxygen Consumption
  • Pain*
  • Virus Diseases / complications