Lupus nephritis is the most common complication of systemic lupus erythematosus (SLE) and an important cause of end-stage kidney disease and death in patients with SLE. The pathogenesis of SLE is complex, with no effective treatment and poor long-term prognosis. The development of genomic medicine provides a new way to explore the disease-causing genes and pathogenesis of lupus nephritis. Here, the article introduces how to uncover the pathogenesis of lupus nephritis from the genome level and explore new strategies for diagnosis and treatment on this disease.
狼疮肾炎为系统性红斑狼疮（SLE）最常见的并发症，是导致终末期肾脏病和SLE患者死亡的重要原因。SLE发病机制复杂，缺乏有效的治疗，患者远期预后差。基因组医学的发展为解析狼疮肾炎的致病基因及发病机制提供了新的路径。本文将阐述如何从基因组层面揭示狼疮肾炎的发病机制，探索疾病诊断和治疗的新策略。.