Antioxidative and Anti-inflammatory Effects of Plant-derived Hypoglycemic Medicines: An In vivo/In vitro Systematic Review

Mohammad Sadegh Adel-Mehraban; Ozra Tabatabaei-Malazy; Azadeh Manayi; Sudabeh Alatab; Shahrzad Mohseni; Saeed Ebrahimi Fana; Pooria Asili; Roodabeh Bahramsoltani; Fataneh Esmaeili; Bayan Azizi

doi:10.2174/0115680266295032240415064750

Antioxidative and Anti-inflammatory Effects of Plant-derived Hypoglycemic Medicines: An In vivo/In vitro Systematic Review

Curr Top Med Chem. 2024 Apr 19. doi: 10.2174/0115680266295032240415064750. Online ahead of print.

Authors

Mohammad Sadegh Adel-Mehraban^{1

2}, Ozra Tabatabaei-Malazy^{3

4}, Azadeh Manayi⁵, Sudabeh Alatab⁶, Shahrzad Mohseni⁴, Saeed Ebrahimi Fana^{7

8}, Pooria Asili⁴, Roodabeh Bahramsoltani⁹, Fataneh Esmaeili⁷, Bayan Azizi¹⁰

Affiliations

¹ Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.
² Traditional Persian Medicine and Complementary Medicine (PerCoMed) Student Association, Student's Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
³ Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
⁴ Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
⁵ Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
⁶ Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
⁷ Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
⁸ Student Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
⁹ Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.
¹⁰ Cardiac Primary Prevention Research Center (CPPRC), Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 38644706
DOI: 10.2174/0115680266295032240415064750

Abstract

Background: The activation of oxidative stress and inflammatory conditions has been associated with acceleration in diabetes (DM) onset and complications. Despite various anti-DM medications, there is a growing trend to discover inexpensive and effective treatments with low adverse effects from plants as one of the promising sources for drug development.

Objective: This study aimed to systematically investigate the simultaneous anti-inflammatory and antioxidant effects of plant-derived hypoglycemic medicines in diabetic experimental models.

Methods: The search terms consisted of "diabetes", "herbal medicine", "antioxidant", "Inflammatory biomarker", and their equivalents among PubMed, Scopus, Web of Science, and Cochrane Library databases up to 17 August 2021.

Results: Throughout the search of databases, 201 eligible experimental studies were recorded. The results showed that the most commonly assessed inflammatory and oxidative stress biomarkers were tumor necrosis factor (TNF)-α, interleukin (IL) 6, IL-1β, IL-10, malondialdehyde (MDA), and nitric oxide (NO). The activity of antioxidant enzymes, including superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT) were assessed in the present review. Among herbal treatments, Trigonella foenum-graecum L., Centella asiatica (L.) Urb., Vitis vinifera L., and Moringa oleifera Lam. were most commonly used for diabetic complications. Due to the dispersion of the treatments, meta-analysis was not applicable.

Conclusion: Our findings showed that the application of different plant-derived hypoglycemic treatments in animal models improved diabetes and its complications, as well as modulated concomitant inflammatory and oxidative stress biomarkers. These findings suggest that plant-based antidiabetic medicines and food supplements have the potential to manage diabetes and its complications.

Keywords: Animal models; Anti-inflammatory biomarkers; Diabetes mellitus; Herbal medicine.; Hyperglycemia; Oxidative stress; Phytotherapy.