Procalcitonin and qSOFA as a Marker of Mortality in Sepsis

Ashaq Hussain Parrey; Manzoor Koka; Basharat Kasana; Mohd Ismail

doi:10.2174/0115748871288534240322083746

Procalcitonin and qSOFA as a Marker of Mortality in Sepsis

Rev Recent Clin Trials. 2024 Apr 19. doi: 10.2174/0115748871288534240322083746. Online ahead of print.

Authors

Ashaq Hussain Parrey¹, Manzoor Koka¹, Basharat Kasana¹, Mohd Ismail¹

Affiliation

¹ Internal Medicine Government Medical College, Srinagar, India.

PMID: 38644718
DOI: 10.2174/0115748871288534240322083746

Abstract

Background: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The qSOFA and procalcitonin are currently used for both diagnostic as well as prognostic purposes.

Objective: To explore the combined use of day one procalcitonin level and qSOFA scores for prognostication of sepsis-related mortality Design: This was a prospective observational study.

Participants: All patients who fulfilled the inclusion criteria for sepsis with an age of more than 16 years were enrolled in the study Results: In this study of 211 patients, 15 patients died (7.1%) during hospital stay. Among the 15 patients who died, the highest mortality of 29.4% qSOFA of "2" had a mortality of 12.8%),qSOFA of "1" had a mortality of 1% and qSOFA of "0" had zero mortality. In this study, procalcitonin had a statistically significant positive correlation/association with both qSOFA and mortality.

Conclusion: The qSOFA and procalcitonin at presentation to the emergency department in septic patients have a significant correlation with mortality in patients hospitalized with sepsis. Obtaining these two parameters at presentation will help in managing aggressively these patients who at presentation have higher qSOFA and procalcitonin levels.

Keywords: CRP.; PCT; Sepsis; mortality; procalcitonin; qSOFA.