Objective: Analyze the impact of hyperbaric oxygen therapy on neuroprotection and recovery post severe traumatic brain injury (sTBI) resuscitation. Methods: Retrospective analysis of clinical data from 83 sTBI patients admitted between January 2022 to January 2024. Patients were divided into control (n = 41) and observation (n = 42) groups based on treatment received. Control received standard therapy, while the observation group received hyperbaric oxygen therapy. Effects on clinical outcomes, neuroinjury markers (S100β, GFAP, UCH-L1, NSE), neurotrophic factors (NGF, BDNF), neurological function indicators (NIHSS, CSS), and adverse reactions were compared. Results: The observation group showed a higher total effective rate (80.95%) compared to control (60.98%) (P < 0.05). Neuroinjury markers decreased post-treatment in both groups, with the observation group lower (P < 0.05). NGF and BDNF levels increased post-treatment in both groups, with the observation group higher (P < 0.05). NIHSS and CSS scores decreased post-treatment in both groups, with the observation group lower (P < 0.05). No significant difference in adverse reactions between groups (P > 0.05). Conclusion: Hyperbaric oxygen therapy effectively treats sTBI by improving brain resuscitation success, reducing neuroinjury factors, enhancing neurotrophic factors, and promoting neurological function recovery, without increasing adverse reaction risk.
Keywords: Hyperbaric oxygen therapy; brain resuscitation; effects; neuroprotection; recovery; severe traumatic brain injury.