Prolapsed lumbar disc treated with intramuscularly administered dexamethasonephosphate. A prospectively planned, double-blind, controlled clinical trial in 52 patients

Scand J Rheumatol. 1979;8(3):142-4. doi: 10.3109/03009747909114446.


Prompted by previously results of systemic steroid treatment of symptoms of prolapsed lumbar disc, which appeared to be promising, dexamethasone phosphate was tested in a controlled, double-blind clinical study. 52 patients were included in the study: 25 received dexamethasone phosphate, 24 received placebo and 3 patients dropped out. Upon termination of the study the two groups were found to be comparable as to age, sex, duration of symptoms and degree of heavy work. We were not able to demonstrate any effect of dexamethasone phosphate on the following parameters pain, paraesthesia, paresismuscular weakness, disturbances of reflexes, and Laseque. Nor was there any difference in the length of hospitalization.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Clinical Trials as Topic
  • Dexamethasone / administration & dosage
  • Dexamethasone / adverse effects
  • Dexamethasone / therapeutic use*
  • Double-Blind Method
  • Female
  • Glycosuria / chemically induced
  • Humans
  • Injections, Intramuscular
  • Intervertebral Disc Displacement / drug therapy*
  • Lumbar Vertebrae
  • Male
  • Middle Aged
  • Placebos
  • Prospective Studies


  • Placebos
  • Dexamethasone