Pneumocystis jirovecii Pneumonia Complicating Use of Upadacitinib in a Patient With Ulcerative Colitis and Primary Sclerosing Cholangitis: A Case Report

Simone Chin; Lucy Fox; Avik Majumdar; Mark Oliver; Matthew C Choy; Peter De Cruz

doi:10.1093/ibd/izae091

Pneumocystis jirovecii Pneumonia Complicating Use of Upadacitinib in a Patient With Ulcerative Colitis and Primary Sclerosing Cholangitis: A Case Report

Inflamm Bowel Dis. 2024 Apr 24:izae091. doi: 10.1093/ibd/izae091. Online ahead of print.

Authors

Simone Chin¹, Lucy Fox², Avik Majumdar^{1

3}, Mark Oliver⁴, Matthew C Choy^{1

3}, Peter De Cruz^{1

3}

Affiliations

¹ Department of Gastroenterology, Austin Health, Melbourne, VIC, Australia.
² Department of Haematology, Austin Health, Melbourne, VIC, Australia.
³ Department of Medicine, Austin Academic Centre, The University of Melbourne, Melbourne, VIC, Australia.
⁴ Department of Gastroenterology, The Royal Children's Hospital, Melbourne, VIC, Australia.

PMID: 38656421
DOI: 10.1093/ibd/izae091

No abstract available

Plain language summary

Pneumocystis jirovecii is a ubiquitous, unicellular fungus that can cause pneumonia (PJP) in immunosuppressed individuals. We report the first case of PJP complicating upadacitinib use for ulcerative colitis. This report is of clinical relevance given the widespread uptake of JAK inhibition.