History of chronic gastritis: How our perceptions have changed

World J Gastroenterol. 2024 Apr 7;30(13):1851-1858. doi: 10.3748/wjg.v30.i13.1851.

Abstract

Currently, the diagnostic strategy for chronic gastritis (CG) is aimed not just at fixing the presence of gastric mucosal inflammation, but also at gastric cancer (GC) risk stratification in a particular patient. Modern classification approach with the definition of the stage of gastritis determines the need, activities and frequency of dynamic monitoring of a patient. However, this attitude to the patient suffering from CG was far from always. The present publication is a literature review describing the key milestones in the history of CG research, from the description of the first observations of inflammation of the gastric mucosa, assessment of gastritis as a predominantly functional disease, to the advent of endoscopy of the upper digestive tract and diagnostic gastric biopsy, assessment of the role of Helicobacter pylori infection in progression of inflammatory changes to atrophy, intestinal metaplasia, dysplasia and GC.

Keywords: Chronic gastritis; Dysplasia; Gastric cancer; Helicobacter pylori; Intestinal metaplasia.

Publication types

  • Review
  • Historical Article

MeSH terms

  • Biopsy
  • Chronic Disease
  • Disease Progression
  • Gastric Mucosa* / microbiology
  • Gastric Mucosa* / pathology
  • Gastritis* / diagnosis
  • Gastritis* / history
  • Gastritis* / microbiology
  • Gastritis* / pathology
  • Helicobacter Infections* / diagnosis
  • Helicobacter Infections* / epidemiology
  • Helicobacter Infections* / history
  • Helicobacter Infections* / microbiology
  • Helicobacter pylori* / isolation & purification
  • History, 19th Century
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Metaplasia
  • Predictive Value of Tests
  • Stomach Neoplasms / diagnosis
  • Stomach Neoplasms / history
  • Stomach Neoplasms / pathology