Dual-Acting Nitric Oxide Donor and Phosphodiesterase Inhibitor TOP-N53 Increases Lifespan and Health Span of Caenorhabditis elegans

Martina Rudgalvyte; Paola Atzei; Rita de Brito Francisco; Reto Naef; Dominique A Glauser

doi:10.17912/micropub.biology.001090

Dual-Acting Nitric Oxide Donor and Phosphodiesterase Inhibitor TOP-N53 Increases Lifespan and Health Span of Caenorhabditis elegans

MicroPubl Biol. 2024 Apr 10:2024:10.17912/micropub.biology.001090. doi: 10.17912/micropub.biology.001090. eCollection 2024.

Authors

Martina Rudgalvyte¹, Paola Atzei², Rita de Brito Francisco², Reto Naef², Dominique A Glauser¹

Affiliations

¹ Dept. Biology, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland.
² TOPADUR Pharma AG, Grabenstrasse 11A, 8952 Schlieren, Switzerland.

Abstract

The quest for extending lifespan and promoting a healthy aging has been a longstanding pursuit in the field of aging research. The control of aging and age-related diseases by nitric oxide (NO) and cGMP signaling is a broadly conserved process from worms to human. Here we show that TOP-N53, a dual-acting NO donor and PDE5 inhibitor, can increase both lifespan and health span in C. elegans .

Grants and funding

The project was financed by the University of Fribourg, the Swiss National Science Foundation (310030_197607 to DAG) and by TOPADUR Pharma AG.