Embryonic microglia maintain the brain's cortical fault lines

Anushree S Gupte; T Yvanka de Soysa; Beth Stevens

doi:10.1016/j.it.2024.04.005

Embryonic microglia maintain the brain's cortical fault lines

Trends Immunol. 2024 May;45(5):327-328. doi: 10.1016/j.it.2024.04.005. Epub 2024 Apr 24.

Authors

Anushree S Gupte¹, T Yvanka de Soysa¹, Beth Stevens²

Affiliations

¹ Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
² Boston Children's Hospital, F.M. Kirby Neurobiology Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA. Electronic address: beth.stevens@childrens.harvard.edu.

PMID: 38664101
DOI: 10.1016/j.it.2024.04.005

Abstract

Lawrence et al. report that fetal cortical boundaries are susceptible to morphogenetic stress that regulates a microglia state resembling postnatal, axon-tract associated microglia (ATM). This state performs a newfound function at these boundaries by preventing the formation of cavitary lesions, mediated in part by Spp1-regulated phagocytosis of fibronectin 1.

MeSH terms

Animals
Brain / embryology
Brain / physiology
Cerebral Cortex / cytology
Cerebral Cortex / embryology
Fibronectins / metabolism
Humans
Microglia* / physiology
Phagocytosis

Substances

Fibronectins