Bictegravir Use During Pregnancy: A Multi-Center Retrospective Analysis Evaluating HIV Viral Suppression and Perinatal Outcomes

Lauren M Holt; William R Short; Florence Momplaisir; Eleanor Hyun; Jennifer McKinney; Andrea Lugo Morales; Alejandra Duque; Brian Druyan; Chima Ndubizu; Luthita Duthely; Naima Joseph; Anandi Sheth; Martina L Badell

doi:10.1093/cid/ciae218

Bictegravir Use During Pregnancy: A Multi-Center Retrospective Analysis Evaluating HIV Viral Suppression and Perinatal Outcomes

Clin Infect Dis. 2024 Apr 26:ciae218. doi: 10.1093/cid/ciae218. Online ahead of print.

Authors

Affiliations

¹ Emory University School of Medicine, Department of Gynecology and Obstetrics, Atlanta GA USA.
² University of Pennsylvania School of Medicine, Department of Internal Medicine, Philadelphia PA, USA.
³ University of Pennsylvania School of Medicine, Department of Internal Medicine Philadelphia PA, USA.
⁴ University of Pennsylvania School of Medicine, Philadelphia PA, USA.
⁵ Baylor College of Medicine, Department of Gynecology and Obstetrics, Houston TX, USA.
⁶ Baylor College of Medicine, Houston TX, USA.
⁷ University of Miami School of Medicine, Department of Gynecology and Obstetrics, Miami FL, USA.
⁸ University of Miami School of Medicine, Miami FL, USA.
⁹ Boston University School of Medicine, Department of Obstetrics and Gynecology, Boston MA.
¹⁰ Emory University School of Medicine, Department of Internal Medicine, Atlanta GA USA.
¹¹ Emory University, Department of Gynecology and Obstetrics, Atlanta GA USA.

PMID: 38666408
DOI: 10.1093/cid/ciae218

Abstract

This study describes the largest cohort to date (n=147) of pregnant patients living with HIV on bictegravir (BIC). BIC in pregnancy was associated with high levels of viral suppression and similar perinatal outcomes to published literature. These findings support consideration for use of BIC in management of HIV during pregnancy.

Keywords: Biktarvy; HIV; Perinatal Outcomes; Pregnancy.

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