Clinical Significance of Serum SCC Levels Before Treatment for Locally Advanced Cervical Squamous Cell Carcinoma

Anticancer Res. 2024 May;44(5):2009-2019. doi: 10.21873/anticanres.17004.


Background/aim: Although serum squamous cell carcinoma (SCC) antigen values are known to be useful in predicting the prognosis of cervical SCC, they have only been examined in a cursory manner. This study aimed to meticulously investigate the clinical significance of serum SCC antigen levels in patients with locally advanced cervical squamous cell carcinoma (LACSC).

Patients and methods: The study included patients who were diagnosed with local stage (T-stage) 1b3/2/3 LACSC and underwent initial treatment at our institute between January 2006 and December 2016 (T-1b3: n=30; T-2: n=75; T-3: n=34). The patients were divided into three groups based on pre-treatment SCC values, and differences in clinical background, laboratory and pathology findings, and prognosis were examined.

Results: No significant difference in the SCC distribution was observed among the T-1b3/2/3 cases with elevated SCC levels. In stages T-1b3, T-2, and T-3, most recurrences in the SCC-High group were distant (T-1b3: three out of five recurrences; T-2: six out of seven recurrences; T-3: four out of eight recurrences), while most recurrences in the SCC-Low group were pelvic (T-1b3: two out of three recurrences; T-2: eight out of eight recurrences; T-3: three out of three recurrences).

Conclusion: In LACSC, serum SCC antigen levels before treatment correlate strongly with the recurrence site. Patients with low levels should be closely monitored for local recurrence, whereas those with high levels warrant vigilance for distant recurrence.

Keywords: Cervical cancer; SCC antigen; distal recurrence; locally advanced cervical squamous cell carcinoma; pelvic recurrence; squamous cell carcinoma.

MeSH terms

  • Adult
  • Aged
  • Antigens, Neoplasm* / blood
  • Biomarkers, Tumor / blood
  • Carcinoma, Squamous Cell* / blood
  • Carcinoma, Squamous Cell* / pathology
  • Carcinoma, Squamous Cell* / therapy
  • Clinical Relevance
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Recurrence, Local* / blood
  • Neoplasm Recurrence, Local* / pathology
  • Neoplasm Staging
  • Prognosis
  • Serpins* / blood
  • Uterine Cervical Neoplasms* / blood
  • Uterine Cervical Neoplasms* / pathology
  • Uterine Cervical Neoplasms* / therapy


  • squamous cell carcinoma-related antigen
  • Serpins
  • Antigens, Neoplasm
  • Biomarkers, Tumor