Zinc and Chronic Kidney Disease: A Review

J Nutr Sci Vitaminol (Tokyo). 2024;70(2):98-105. doi: 10.3177/jnsv.70.98.


Chronic kidney disease (CKD) poses a major global public health challenge. The World Health Organization's data shows that CKD affects about 10% of the world's population, particularly in low- and middle-income countries. Due to limited access to diagnosis and treatment, CKD has become the 12th leading cause of death worldwide. The advanced stage of CKD can lead to kidney failure, which is clinically referred to as end-stage renal disease (ESRD). In such cases, patients can only sustain life through dialysis or kidney transplantation. However, the long-term affordability of these treatments remains low. Moreover, the effectiveness of kidney transplantation is modest, posing a significant treatment barrier in resource-limited settings, and significantly impacting patient survival. To address this issue, we suggest using dietary supplementation of the trace element zinc to impede CKD development and prolong patient survival.

Keywords: chronic kidney disease; homeostasis; inflammation; oxidative stress; zinc.

Publication types

  • Review

MeSH terms

  • Dietary Supplements*
  • Humans
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / therapy
  • Kidney Transplantation
  • Renal Dialysis
  • Renal Insufficiency, Chronic* / complications
  • Renal Insufficiency, Chronic* / therapy
  • Trace Elements / administration & dosage
  • Trace Elements / therapeutic use
  • Zinc* / administration & dosage
  • Zinc* / deficiency
  • Zinc* / therapeutic use


  • Zinc
  • Trace Elements