Development and validation of a high-performance thin-layer chromatography method for detection of sibutramine in dietary supplements

Folia Med (Plovdiv). 2024 Apr 30;66(2):255-263. doi: 10.3897/folmed.66.e121218.

Abstract

In the period between 1997 and 2010, sibutramine-containing drugs were widely prescribed for obesity and over-weight management. Due to safety concerns, in 2010 all medicines containing sibutramine were urgently withdrawn from the USA and European pharmaceutical market. Although sibutramine is no longer available in pharmaceutical products, there have been numerous reports of mislabeled weight-loss dietary supplements containing sibutramine.

Keywords: dietary supplements food supplements high-performance thin-layer chromatography HPTLC sibutramine.

Publication types

  • Validation Study

MeSH terms

  • Appetite Depressants* / analysis
  • Chromatography, Thin Layer / methods
  • Cyclobutanes* / analysis
  • Dietary Supplements* / analysis
  • Humans

Substances

  • Cyclobutanes
  • sibutramine
  • Appetite Depressants