The International Society for Heart and Lung Transplantation (ISHLT): 2024 infection definitions for durable and acute mechanical circulatory support devices

Saima Aslam; Jennifer Cowger; Palak Shah; Valentina Stosor; Hannah Copeland; Anna Reed; David Morales; Gerard Giblin; Jacob Mathew; Orla Morrissey; Paola Morejon; Alina Nicoara; Ezequiel Molina

doi:10.1016/j.healun.2024.03.004

The International Society for Heart and Lung Transplantation (ISHLT): 2024 infection definitions for durable and acute mechanical circulatory support devices

J Heart Lung Transplant. 2024 May 1:S1053-2498(24)01526-2. doi: 10.1016/j.healun.2024.03.004. Online ahead of print.

Authors

Saima Aslam¹, Jennifer Cowger², Palak Shah³, Valentina Stosor⁴, Hannah Copeland⁵, Anna Reed⁶, David Morales⁷, Gerard Giblin⁸, Jacob Mathew⁹, Orla Morrissey¹⁰, Paola Morejon¹¹, Alina Nicoara¹², Ezequiel Molina¹³

Affiliations

¹ Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, California. Electronic address: saslam@ucsd.edu.
² Division of Cardiology, Henry Ford Health, Detroit, Michigan.
³ Inova Heart and Vascular Institute, Falls Church, Virginia.
⁴ Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
⁵ Department of Surgery, Lutheran Hospital of Indiana/Indiana School of Medicine, Fort Wayne, Indiana.
⁶ Respiratory & Transplant Medicine, Royal Brompton and Harefield Hospitals, Harefield, United Kingdom.
⁷ Division of Cardiothoracic Surgery, Department of Surgery, Cincinnati Children's Hospital, Cincinnati, Ohio.
⁸ Cardiology Unit, Mater Misericordiae University Hospital, Dublin, Ireland.
⁹ Cardiology Department, Royal Children's Hospital, Melbourne, Australia.
¹⁰ Department of Infectious Diseases, Monash University and Physician at Alfred Health, Melbourne, Australia.
¹¹ Cardiology, Clinica Guayaquil, Guayaquil, Ecuador.
¹² Division of Cardiothoracic Anesthesia, Duke University, Durham, North Carolina.
¹³ Samsky Heart Failure Center, Piedmont Heart Institute, Atlanta, Georgia.

PMID: 38691077
DOI: 10.1016/j.healun.2024.03.004

Abstract

Infections remain a significant concern in patients receiving mechanical circulatory support (MCS), encompassing both durable and acute devices. This consensus manuscript provides updated definitions for infections associated with durable MCS devices and new definitions for infections in acute MCS, integrating a comprehensive review of existing literature and collaborative discussions among multidisciplinary specialists. By establishing consensus definitions, we seek to enhance clinical care, facilitate consistent reporting in research studies, and ultimately improve outcomes for patients receiving MCS.

Keywords: ECMO; LVAD; MCS; definitions; infection.

Publication types

Practice Guideline