Intermittent Versus Sustained Hypoxemia from Sleep-disordered Breathing: Outcomes in Patients with Chronic Lung Disease and High Altitude

Alyssa A Self; Omar A Mesarwi

doi:10.1016/j.jsmc.2024.02.011

Intermittent Versus Sustained Hypoxemia from Sleep-disordered Breathing: Outcomes in Patients with Chronic Lung Disease and High Altitude

Sleep Med Clin. 2024 Jun;19(2):327-337. doi: 10.1016/j.jsmc.2024.02.011. Epub 2024 Mar 21.

Authors

Alyssa A Self¹, Omar A Mesarwi²

Affiliations

¹ Division of Pulmonary, Critical Care, and Sleep Medicine and Physiology, University of California, San Diego, 9500 Gilman Drive Mail Code 0623A, La Jolla, CA 92093, USA.
² Division of Pulmonary, Critical Care, and Sleep Medicine and Physiology, University of California, San Diego, 9500 Gilman Drive Mail Code 0623A, La Jolla, CA 92093, USA. Electronic address: omesarwi@health.ucsd.edu.

PMID: 38692756
DOI: 10.1016/j.jsmc.2024.02.011

Abstract

In a variety of physiologic and pathologic states, people may experience both chronic sustained hypoxemia and intermittent hypoxemia ("combined" or "overlap" hypoxemia). In general, hypoxemia in such instances predicts a variety of maladaptive outcomes, including excess cardiovascular disease or mortality. However, hypoxemia may be one of the myriad phenotypic effects in such states, making it difficult to ascertain whether adverse outcomes are primarily driven by hypoxemia, and if so, whether these effects are due to intermittent versus sustained hypoxemia.

Keywords: Cardiometabolic outcomes; Combined hypoxia; Overlap hypoxia; Sleep apnea.

Publication types

Review

MeSH terms

Altitude*
Chronic Disease
Humans
Hypoxia*
Lung Diseases / complications
Sleep Apnea Syndromes* / complications
Sleep Apnea Syndromes* / therapy