Gram-scale approach for β-costic acid via allylic oxidation of β-selinene

Yoshitaka Matsushima; Kosuke Iwata

doi:10.1093/bbb/zbae052

Gram-scale approach for β-costic acid via allylic oxidation of β-selinene

Biosci Biotechnol Biochem. 2024 May 1:zbae052. doi: 10.1093/bbb/zbae052. Online ahead of print.

Authors

Yoshitaka Matsushima¹, Kosuke Iwata¹

Affiliation

¹ Department of Agricultural Chemistry, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.

PMID: 38692843
DOI: 10.1093/bbb/zbae052

Abstract

β-Costic acid is a sesquiterpene phytoalexin with acaricidal activity against Varroa destructor and antitrypanosomal activity. A concise and efficient method was developed for the synthesis of β-costic acid via the allylic oxidation of β-selinene, a component of celery seed oil.

Keywords: acaricidal activity; allylic oxidation; phytoalexin; β-costic acid; β-selinene.