Highlight of 2023: CAR T cells driving precision therapy for autoimmune disease

Immunol Cell Biol. 2024 May 1. doi: 10.1111/imcb.12766. Online ahead of print.

Abstract

CAR T cell therapy is showing remarkable results in autoimmune disease with treatment-refractory patients showing durable drug-free remission. Here, we highlight five key papers from 2023 that are driving the development of CAR T cells to improve precision, safety, efficacy and accessibility for the treatment of autoantibody-associated autoimmune diseases.

Keywords: Autoantibodies; B cells; CAR T cells; autoimmune disease; cellular therapy.