Highlight of 2023: CAR T cells driving precision therapy for autoimmune disease

Adrian Ys Lee; Joanne H Reed

doi:10.1111/imcb.12766

Highlight of 2023: CAR T cells driving precision therapy for autoimmune disease

Immunol Cell Biol. 2024 Jul;102(6):437-440. doi: 10.1111/imcb.12766. Epub 2024 May 1.

Authors

Adrian Ys Lee^{1

2}, Joanne H Reed¹

Affiliations

¹ Centre for Immunology and Allergy Research, Westmead Institute for Medical Research and Faculty of Medicine and Health, University of Sydney, Westmead, NSW, Australia.
² Department of Immunology, Westmead Hospital and Institute of Clinical Pathology and Medical Research, NSW Health Pathology, Westmead, NSW, Australia.

PMID: 38693765
DOI: 10.1111/imcb.12766

Abstract

CAR T cell therapy is showing remarkable results in autoimmune disease with treatment-refractory patients showing durable drug-free remission. Here, we highlight five key papers from 2023 that are driving the development of CAR T cells to improve precision, safety, efficacy and accessibility for the treatment of autoantibody-associated autoimmune diseases.

Keywords: Autoantibodies; B cells; CAR T cells; autoimmune disease; cellular therapy.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autoimmune Diseases* / immunology
Autoimmune Diseases* / therapy
Humans
Immunotherapy, Adoptive* / adverse effects
Immunotherapy, Adoptive* / methods
Precision Medicine*
Receptors, Antigen, T-Cell / immunology
Receptors, Antigen, T-Cell / metabolism
Receptors, Chimeric Antigen* / immunology
Receptors, Chimeric Antigen* / metabolism
T-Lymphocytes / immunology

Substances

Receptors, Chimeric Antigen
Receptors, Antigen, T-Cell