eIF4G as a switch for heat shock mRNA translation

Mol Cell. 2024 May 2;84(9):1633-1634. doi: 10.1016/j.molcel.2024.04.002.


The heat shock response is crucial for cell survival. In this issue of Molecular Cell, Desroches Altamirano et al.1 demonstrate that a temperature-induced conformational change in the translation initiation factor eIF4G is a key mechanism regulating translation during the heat shock response.

Publication types

  • Comment

MeSH terms

  • Animals
  • Eukaryotic Initiation Factor-4G* / genetics
  • Eukaryotic Initiation Factor-4G* / metabolism
  • Heat-Shock Proteins / genetics
  • Heat-Shock Proteins / metabolism
  • Heat-Shock Response*
  • Humans
  • Protein Biosynthesis*
  • Protein Conformation
  • RNA, Messenger* / genetics
  • RNA, Messenger* / metabolism


  • Eukaryotic Initiation Factor-4G
  • RNA, Messenger
  • Heat-Shock Proteins