Unveiling the mystery of nuclear RNA homeostasis

Cell Stem Cell. 2024 May 2;31(5):583-585. doi: 10.1016/j.stem.2024.03.014.

Abstract

How nuclear RNA homeostasis impacts cellular functions remains elusive. In this issue of Cell Stem Cell, Han et al.1 utilized a controllable protein degradation system targeting EXOSC2 to perturb RNA homeostasis in mouse pluripotent embryonic stem cells, revealing its vital role in orchestrating crucial nuclear events for cellular fitness.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Nucleus / metabolism
  • Exosome Multienzyme Ribonuclease Complex / genetics
  • Exosome Multienzyme Ribonuclease Complex / metabolism
  • Homeostasis*
  • Humans
  • Mice
  • Mouse Embryonic Stem Cells / cytology
  • Mouse Embryonic Stem Cells / metabolism
  • Pluripotent Stem Cells / cytology
  • Pluripotent Stem Cells / metabolism
  • RNA / metabolism
  • RNA, Nuclear* / genetics
  • RNA, Nuclear* / metabolism
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism

Substances

  • RNA, Nuclear
  • Exosome Multienzyme Ribonuclease Complex
  • RNA-Binding Proteins
  • RNA