Abstract
How nuclear RNA homeostasis impacts cellular functions remains elusive. In this issue of Cell Stem Cell, Han et al.1 utilized a controllable protein degradation system targeting EXOSC2 to perturb RNA homeostasis in mouse pluripotent embryonic stem cells, revealing its vital role in orchestrating crucial nuclear events for cellular fitness.
Copyright © 2024 Elsevier Inc. All rights reserved.
MeSH terms
-
Animals
-
Cell Nucleus / metabolism
-
Exosome Multienzyme Ribonuclease Complex / genetics
-
Exosome Multienzyme Ribonuclease Complex / metabolism
-
Homeostasis*
-
Humans
-
Mice
-
Mouse Embryonic Stem Cells / cytology
-
Mouse Embryonic Stem Cells / metabolism
-
Pluripotent Stem Cells / cytology
-
Pluripotent Stem Cells / metabolism
-
RNA / metabolism
-
RNA, Nuclear* / genetics
-
RNA, Nuclear* / metabolism
-
RNA-Binding Proteins / genetics
-
RNA-Binding Proteins / metabolism
Substances
-
RNA, Nuclear
-
Exosome Multienzyme Ribonuclease Complex
-
RNA-Binding Proteins
-
RNA