Thyroid receptor β: A promising target for developing novel anti-androgenetic alopecia drugs

Jia Zhi; Feifan Li; Xiaoying Jiang; Renren Bai

doi:10.1016/j.drudis.2024.104013

Thyroid receptor β: A promising target for developing novel anti-androgenetic alopecia drugs

Drug Discov Today. 2024 Jun;29(6):104013. doi: 10.1016/j.drudis.2024.104013. Epub 2024 May 3.

Authors

Jia Zhi¹, Feifan Li¹, Xiaoying Jiang², Renren Bai³

Affiliations

¹ School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P.R. China; Key Laboratory of Elemene Class Anti-tumor Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China.
² School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P.R. China; Key Laboratory of Elemene Class Anti-tumor Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China. Electronic address: xyjiang@hznu.edu.cn.
³ School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P.R. China; Key Laboratory of Elemene Class Anti-tumor Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, PR China. Electronic address: renrenbai@hznu.edu.cn.

PMID: 38705510
DOI: 10.1016/j.drudis.2024.104013

Abstract

Androgenetic alopecia (AGA) significantly impacts the self-confidence and mental well-being of people. Recent research has revealed that thyroid receptor β (TRβ) agonists can activate hair follicles and effectively stimulate hair growth. This review aims to comprehensively elucidate the specific mechanism of action of TRβ in treating AGA from various perspectives, highlighting its potential as a drug target for combating AGA. Moreover, this review provides a thorough summary of the research advances in TRβ agonist candidates with anti-AGA efficacy and outlines the structure-activity relationships (SARs) of TRβ agonists. We hope that this review will provide practical information for the development of effective anti-alopecia drugs.

Keywords: TRβ agonists; androgenetic alopecia (AGA); drug discovery; structure–activity relationship (SAR); thyroid receptor β (TRβ).

Publication types

Review

MeSH terms

Alopecia* / drug therapy
Animals
Drug Development / methods
Hair Follicle / drug effects
Hair Follicle / metabolism
Humans
Molecular Targeted Therapy
Structure-Activity Relationship
Thyroid Hormone Receptors beta* / agonists
Thyroid Hormone Receptors beta* / metabolism

Substances

Thyroid Hormone Receptors beta