A hypernychthemeral sleep-wake syndrome: a treatment attempt

Chronobiol Int. 1985;2(4):277-80. doi: 10.3109/07420528509055890.


The wake and sleep-onset times of a patient with a sleep-wake cycle longer than 24 hr were recorded by the patient for 4 years. During this time, the patient found himself unable to maintain a 24-hr sleep-wake schedule. When treated with 1-2 mg clonazepam, taken nightly, he was able to become entrained to a 24-hr day. Despite entrainment of his sleep-wake cycle, the patient reported depression, lack of motivation and fatigue and chose not to continue taking the drug.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Circadian Rhythm*
  • Clonazepam / therapeutic use*
  • Depression / etiology
  • Fatigue / etiology
  • Humans
  • Male
  • Sleep Wake Disorders / complications
  • Sleep Wake Disorders / drug therapy*


  • Clonazepam