Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing

Feixue Mi; Zhao Liu; Xinyu Wang; Yingjie Wang; Junfeng Yang; Zhe Wang; Shengyan Yin; Xiaofeng Fang; Peng Shu; Xuanjun Zhang; Changfeng Wu

doi:10.1002/anie.202402133

Deep Red Light Driven Hydrogen Evolution by Heterojunction Polymer Dots for Diabetic Wound Healing

Angew Chem Int Ed Engl. 2024 May 6:e202402133. doi: 10.1002/anie.202402133. Online ahead of print.

Authors

Feixue Mi¹, Zhao Liu², Xinyu Wang¹, Yingjie Wang³, Junfeng Yang⁴, Zhe Wang⁴, Shengyan Yin⁴, Xiaofeng Fang¹, Peng Shu², Xuanjun Zhang⁵, Changfeng Wu⁶

Affiliations

¹ Southern University of Science and Technology, Optical Molecule and Skin Imaging Joint Laboratory, Department of Biomedical Engineering, CHINA.
² Shenzhen Hujia Technology Co Ltd, HBN Research Institute and Biological Laboratory, CHINA.
³ Shenzhen Bay Laboratory, Institute of Systems and Physical Biology, CHINA.
⁴ Jilin University, State Key Laboratory of Integrated Optoelectronic, College of Electronic Science and Engineering, CHINA.
⁵ University of Macau, Faculty of Health Sciences, CHINA.
⁶ Southern University of Science and Technology, Biomedical Engineering, 1088 Xueyuan Road, 518055, Shenzhen, CHINA.

PMID: 38708621
DOI: 10.1002/anie.202402133

Abstract

We describe small heterojunction polymer dots (Pdots) with deep-red light catalyzed H2 generation for diabetic skin wound healing. The Pdots with donor/acceptor heterojunctions showed remarkably enhanced photocatalytic activity as compared to the donor or acceptor nanoparticles alone. We encapsulate the Pdots and ascorbic acid into liposomes to form Lipo-Pdots nanoreactors, which selectively scavenge •OH radicals in live cells and tissues under 650 nm light illumination. The antioxidant capacity of the heterojunction Pdots is ~10 times higher than that of the single-component Pdots described previously. Under a total light dose of 360 J/cm2, the Lipo-Pdots nanoreactors effectively scavenged •OH radicals and suppressed the expression of pro-inflammatory cytokines in skin tissues, thereby accelerating the healing of skin wounds in diabetic mice. This study provides a feasible solution for safe and effective treatment of diabetic foot ulcers.

Keywords: photocatalysis * hydrogen evolution * heterojunction polymer dots * diabetic wound healing.