Abstract
Access to 1,2,3-triazolium-grafted peptoid macrocycles was developed by macrocyclization and multivalent postmodification of linear peptoid oligomers carrying an alternance of benzylic and propargyl groups as side chains. X-ray analysis and NMR studies revealed a conformational preference for constrained hairpin-shaped structures leading to the facial amphipathic character of these macrocycles. A preliminary evaluation showed the antimicrobial activities of these new cationic amphipathic architectures.
MeSH terms
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Anti-Bacterial Agents* / chemical synthesis
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / pharmacology
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Bacteria / drug effects
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Crystallography, X-Ray
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Macrocyclic Compounds* / chemical synthesis
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Macrocyclic Compounds* / chemistry
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Macrocyclic Compounds* / pharmacology
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Microbial Sensitivity Tests*
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Molecular Structure
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Peptidomimetics* / chemical synthesis
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Peptidomimetics* / chemistry
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Peptidomimetics* / pharmacology
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Peptoids / chemical synthesis
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Peptoids / chemistry
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Peptoids / pharmacology
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Triazoles* / chemistry
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Triazoles* / pharmacology