In older patients with AF and frailty, switching from VKA to NOAC therapy increased a composite of major or CRNM bleeding at 12 mo

Ann Intern Med. 2024 May;177(5):JC57. doi: 10.7326/J24-0024. Epub 2024 May 7.

Abstract

Joosten LP, van Doorn S, van de Ven PM, et al. Safety of switching from a vitamin K antagonist to a non-vitamin K antagonist oral anticoagulant in frail older patients with atrial fibrillation: results of the FRAIL-AF randomized controlled trial. Circulation. 2024;149:279-289. 37634130.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anticoagulants* / administration & dosage
  • Anticoagulants* / adverse effects
  • Anticoagulants* / therapeutic use
  • Atrial Fibrillation* / complications
  • Atrial Fibrillation* / drug therapy
  • Drug Substitution
  • Female
  • Frail Elderly
  • Frailty
  • Hemorrhage* / chemically induced
  • Humans
  • Male
  • Stroke / prevention & control
  • Vitamin K* / antagonists & inhibitors